Tools Request permission Export citation Add to favorites Track citation. Share Give access Share full text access. Share full text access. Please review our Terms and Conditions of Use and check box below to share full-text version of article. Abstract Harmful materials in the blood are prevented from entering the healthy brain by a highly selective blood—brain barrier BBB , and impairment of barrier function has been associated with a variety of neurological diseases.
Figure 1 Open in figure viewer PowerPoint. Numbers mm indicate the dimension of our microfluidic model. After 3 d, collagen type 1 4. Statistical analysis was by Student's t test. Figure 2 Open in figure viewer PowerPoint. Permeability increase in the AD model. The images were recorded initially top and at s bottom after adding the dextran. Figure 3 Open in figure viewer PowerPoint. Figure 4 Open in figure viewer PowerPoint.
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Figure 5 Open in figure viewer PowerPoint. Demonstration of influx of neurotoxins through the impaired BBB and its effects on neural cell damage, and a possible application of drug evaluation for a BBB enhancer.
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Dead cells were shown in red. Cell death was analyzed by counting dead cells red in ROI in 0. Acknowledgements Y. Conflict of Interest The authors declare no conflict of interest.
Suppression of transcytosis regulates zebrafish blood-brain barrier function | eLife
Supporting Information Filename Description advssupS1. References 1 R. Tanzi , L. Bertram , Cell , , Crossref Google Scholar.
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Forgot password? About this book Evolving technologies starting with tracer studies, and more recently with genomics and proteomics, have provided novel information about the molecular properties of cerebral endothelium and astrocytes; however, further studies must be done in animal models of neurological diseases and in humans to get a clearer understanding of the pathogenesis of blood-brain barrier BBB breakdown in nervous system diseases. Show all. Aaron et al. Show next xx.
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